SEcondary Malignoma - Prospective Evaluation of the Radiotherapeutic dose distribution as the cause for induction
Based on the development of novel linear accelerator models, new radiation treatment techniques such as IMRT
(Intensity Modulated Radiation Therapy), IGRT (Image Guided Radiation Therapy und VMAT (Volumetric Modulated
Arc Therapy) become applicable. According to the EU - directive 97/43, these techniques allow the theoretically
best possible radiation dose distribution to preserve the normal tissue with highest possible effect on the
underlying tumor. Note that these effects only hold for high doses. As a negative site effect by using the
mentioned techniques, considerably large volumes of the body of the patient will get "contaminated" with
small or minimal doses.
Well known radiobiologists such as Trott and Tubiana claim that radiation with minimal dose is the reason
for the induction of secondary malignancy which often occurs several decades after the particular treatment. This
and the steep dose gradient in conventionally used techniques might explain the nowadays quite little fraction
observed of patients treated by radiotherapy having secondary malignancy compared to expected data. In order to
prove or disapprove that appropriate data sets are not available so far.
From 2012 on radiation therapy techniques like IMRT and VMAT will be available at the Department of
Therapeutic Radiology and Oncology, Medical University Innsbruck providing best high dose conformity but
simultaneously contaminating the patient with minimal doses of to larger areas of healthy tissue the target
volume is located in.
The objective of this project is to develop the platform and framework to perform a long term (range ~ 20 years)
study based on the preconditions given by this new radiotherapy technology.
In order to tackle the problem, we plan to develop a technology for providing a platform to collect and archive
data from patients who were treated by these special techniques and to perform temporary intermediate evaluations.
Medical University Innsbruck / Department of Therapeutic Radiology and Oncology Innsbruck (ROI)
Tiroler Landeskrankenanstalten (TILAK)
ELEKTA Oncology Systems
The project is currently in the initial phase.